CYP2C9 Totally Explained

Everything about Cyp2c9 totally explained

. | PDB =,, | Name = Cytochrome P450, family 2, subfamily C, polypeptide 9 | HGNCid = 2623 | Symbol = CYP2C9 | AltSymbols =; CYP2C; CPC9; CYP2C10; MGC149605; MGC88320; P450 MP-4; P450 PB-1; P450IIC9 | OMIM = 601130 | ECnumber = | Homologene = 86657 | MGIid = 103238 | GeneAtlas_image1 = PBB_GE_CYP2C9_214421_x_at_tn.png | GeneAtlas_image2 = PBB_GE_CYP2C9_216025_x_at_tn.png | GeneAtlas_image3 = PBB_GE_CYP2C9_216661_x_at_tn.png | Function = | Component = | Process = | Orthologs = }} Cytochrome P450 2C9 (abbreviated CYP2C9), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. It is involved in the metabolism of several important groups of drugs including many non-steroidal anti-inflammatory drugs (NSAIDs) and sulfonylureas. Genetic polymorphism exists for CYP2C9 expression, with approximately 1–3% of Caucasian populations being poor metabolisers with no CYP2C9 function.

CYP2C9 Ligands

Selected inducers, inhibitors and substrates of CYP2C9> NSAIDs (analgesic, antipyretic, anti-inflammatory)

phenytoin (antiepileptic)

fluvastatin (statin)

sulfonylurea (antidiabetic)

angiotensin II receptor antagonists (in hypertension, diabetic nephropathy, CHF)

S-warfarin (anticoagulant) Other:

sildenafil (in erectile dysfunction)

terbinafine (antifungal)

miconazole (antifungal)

amitriptyline (tricyclic antidepressant)

pitavastatin (statin)

rosiglitazone (antidiabetic)

tamoxifen (SERM)

cannabinoids (psychoactive)

Substrates	Inhibitors	Inducers
sulfaphenazole (antibacterial) fluconazole (antifungal) Valproic acid (anticonvulsant, mood-stabilizing) others: amiodarone (antiarrhythmic) cimetidine (H2-receptor antagonist) fenofibrate (fibrate) fluvastatin (statin) fluvoxamine (SSRI) isoniazid (in tuberculosis) lovastatin (statin) probenecid (uricosuric) sertraline (SSRI) sulfamethoxazole (antibiotic) teniposide (chemotherapeutic) voriconazole (antifungal) zafirlukast (leukotriene antagonist)	rifampicin (bactericidal) Other: hyperforin (constituent of St John's Wort) secobarbital (barbiturate) aprepitant (anti-emetic)

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